Due to economic and ecological factors, catalytic processes in the pro duction of fine chemicals are gaining in importance, especially in the area of asymmetric catalysis (Collins et al. 1997; Breuer et al. 2004). Accordingly, the practicing chemist has three major options: transition metal catalysts (Jacobsen et al. 1999), organocatalysts (Berkessel and Gröger 2004) or enzymes (Drauz and Waldmann 2002; Liese et al. 2006). All of them have advantages and disadvantages, which means that a given type of catalysis cannot be expected to provide general so lutions to all problems of relevance in academic and industrial labora tories. Therefore, research in all three approaches needs to be intensified.
Manfred T. Reetz, "Controlling the Selectivity and Stability of Proteins by New Strategies in Directed Evolution: The Case of Organocatalytic Enzymes", in Organocatalysis (2008) edited by M.T. Reetz, B. List, S. Jaroch, H. Weinmann.